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    <title>Pathophilia</title>
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    <id>tag:bmartinmd.com,2007-10-12://1</id>
    <updated>2012-02-03T20:47:33Z</updated>
    <subtitle>For the love of disease.</subtitle>
    <generator uri="http://www.sixapart.com/movabletype/">Movable Type Publishing Platform 4.01</generator>

<entry>
    <title>Kick-Back Friday: #193</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/02/kickback-friday-193.html" />
    <id>tag:bmartinmd.com,2012://1.1179</id>

    <published>2012-02-03T20:01:53Z</published>
    <updated>2012-02-03T20:47:33Z</updated>

    <summary>Pimpernel Smith (1941) is Leslie Howard&apos;s updated riff on his previous leading role in The Scarlet Pimpernel (1934), the classic espionage adventure of rescue set during the French Revolution. In the former movie, released just 2 years before Howard&apos;s shocking...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
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    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Pimpernel Smith (1941) is Leslie Howard&apos;s updated riff on his previous leading role in The Scarlet Pimpernel (1934), the classic espionage adventure of rescue set during the French Revolution. In the former movie, released just 2 years before Howard&apos;s shocking...
        
    </content>
</entry>

<entry>
    <title>Alzheimer Biomarkers Less Meaningful With Advancing Age</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/02/ad-biomarkers.html" />
    <id>tag:bmartinmd.com,2012://1.1178</id>

    <published>2012-02-02T14:36:21Z</published>
    <updated>2012-02-04T15:34:48Z</updated>

    <summary>Two articles in this week&apos;s Neurology consider the significance of biomarkers for Alzheimer disease in the cognitively normal elderly.Essentially confirming a recently published Mayo Clinic study, investigators from Texas reported the high prevalence of beta amyloid deposits (detected with Avid...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Epidemiology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neuropsychiatry" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="alzheimersdisease" label="Alzheimer&apos;s disease" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Two articles in this week&apos;s Neurology consider the significance of biomarkers for Alzheimer disease in the cognitively normal elderly.Essentially confirming a recently published Mayo Clinic study, investigators from Texas reported the high prevalence of beta amyloid deposits (detected with Avid...
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #192</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/kickback-friday-192.html" />
    <id>tag:bmartinmd.com,2012://1.1177</id>

    <published>2012-01-27T17:16:01Z</published>
    <updated>2012-01-27T18:43:35Z</updated>

    <summary>Watching The Final Countdown (1980), starring the recently departed James Farentino, is more of an exercise in &quot;How could I make this movie really good?&quot; as opposed to recognizing its few merits—one of which is the evergreen premise of rewriting...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Watching The Final Countdown (1980), starring the recently departed James Farentino, is more of an exercise in &quot;How could I make this movie really good?&quot; as opposed to recognizing its few merits—one of which is the evergreen premise of rewriting...
        
    </content>
</entry>

<entry>
    <title>Harvard Analysts ID Sources of Medicare-Spending Gap</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/harvard-sgr-hole.html" />
    <id>tag:bmartinmd.com,2012://1.1176</id>

    <published>2012-01-26T14:55:01Z</published>
    <updated>2012-01-30T13:56:22Z</updated>

    <summary>Implementation of the Sustainable Growth Rate, or SGR, formula—the formula ostensibly used to control Medicare spending and physician reimbursement for Medicare services—has been stayed numerous times since it was legislated in the late 1990s. As Harvard policy analysts describe in...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Legislation" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Medicare" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="medicare" label="Medicare" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Implementation of the Sustainable Growth Rate, or SGR, formula—the formula ostensibly used to control Medicare spending and physician reimbursement for Medicare services—has been stayed numerous times since it was legislated in the late 1990s. As Harvard policy analysts describe in...
        
    </content>
</entry>

<entry>
    <title>Favorable Early Results of Embryonic Stem Cells in Macular Degeneration</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/early-results-hesc-macular-degen.html" />
    <id>tag:bmartinmd.com,2012://1.1175</id>

    <published>2012-01-24T16:07:43Z</published>
    <updated>2012-01-30T13:59:01Z</updated>

    <summary>At last, something positive (albeit very preliminary) to report about the use of human embryonic stem cells (hESCs)...in disease, no less.Yesterday The Lancet published (and made freely available—!) early safety results from Advanced Cell Technology&apos;s 2 prospective phase 1/2 clinical...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ophthalmology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="maculardegeneration" label="macular degeneration" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="stemcells" label="stem cells" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        At last, something positive (albeit very preliminary) to report about the use of human embryonic stem cells (hESCs)...in disease, no less.Yesterday The Lancet published (and made freely available—!) early safety results from Advanced Cell Technology&apos;s 2 prospective phase 1/2 clinical...
        
    </content>
</entry>

<entry>
    <title>Who the Hell Was John Cunningham?</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/who-the-hell-was-john-cunningham.html" />
    <id>tag:bmartinmd.com,2012://1.1174</id>

    <published>2012-01-23T16:29:16Z</published>
    <updated>2012-01-26T17:28:40Z</updated>

    <summary>Friday the FDA announced that it&apos;s permitting the marketing of the first test for antibodies to the JC virus (Stratify JCV Antibody ELISA test; Quest Diagnostics), the cause of progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals and now an official...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Medical history" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="medicalhistory" label="medical history" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="pml" label="PML" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Friday the FDA announced that it&apos;s permitting the marketing of the first test for antibodies to the JC virus (Stratify JCV Antibody ELISA test; Quest Diagnostics), the cause of progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals and now an official...
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #191</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/kickback-friday-191.html" />
    <id>tag:bmartinmd.com,2012://1.1173</id>

    <published>2012-01-20T22:00:15Z</published>
    <updated>2012-01-27T14:43:41Z</updated>

    <summary>&quot;Life on Mars&quot; (2006-2007): A modern-day Manchester policeman (played by the terrific John Simm) is transported back to politically incorrect 1973 after being struck by a car. Is he mad, in a coma, or back in time? The nifty opener...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        &quot;Life on Mars&quot; (2006-2007): A modern-day Manchester policeman (played by the terrific John Simm) is transported back to politically incorrect 1973 after being struck by a car. Is he mad, in a coma, or back in time? The nifty opener...
        
    </content>
</entry>

<entry>
    <title>Deen, Novo Taken DOWN...Well, Verbally at Least</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/deen-novo-taken-down.html" />
    <id>tag:bmartinmd.com,2012://1.1172</id>

    <published>2012-01-20T17:40:23Z</published>
    <updated>2012-01-20T17:54:46Z</updated>

    <summary>In a Pharmalot interview, money manager, blogger, and diabetic David Kliff absolutely excoriates &quot;Buttah Queen&quot; Paula Deen and insulin-maker Novo Nordisk for their newly announced, and arguably duplicitous, promotional relationship. Kliff easily tosses out words like &quot;hypocrite,&quot; &quot;shyster,&quot; and &quot;bastardizing&quot;...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Endocrinology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Health care" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Media" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="diabetes" label="diabetes" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="media" label="Media" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        In a Pharmalot interview, money manager, blogger, and diabetic David Kliff absolutely excoriates &quot;Buttah Queen&quot; Paula Deen and insulin-maker Novo Nordisk for their newly announced, and arguably duplicitous, promotional relationship. Kliff easily tosses out words like &quot;hypocrite,&quot; &quot;shyster,&quot; and &quot;bastardizing&quot;...
        
    </content>
</entry>

<entry>
    <title>Dimebon Development for Alzheimer&apos;s Officially Dead</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/dimebon-development-for-ad-dead.html" />
    <id>tag:bmartinmd.com,2012://1.1171</id>

    <published>2012-01-18T15:07:57Z</published>
    <updated>2012-01-18T15:48:30Z</updated>

    <summary>Medivation and partner Pfizer will cease development of Dimebon (latrepirdine), a now thoroughly defunct antihistamine, &quot;for all indications and will terminate the ongoing open label extension study in Alzheimer&apos;s disease.&quot; The small biopharm company announced the official end of Dimebon...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neuropsychiatry" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="alzheimersdisease" label="Alzheimer&apos;s disease" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Medivation and partner Pfizer will cease development of Dimebon (latrepirdine), a now thoroughly defunct antihistamine, &quot;for all indications and will terminate the ongoing open label extension study in Alzheimer&apos;s disease.&quot; The small biopharm company announced the official end of Dimebon...
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #190</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/kickback-friday-190.html" />
    <id>tag:bmartinmd.com,2012://1.1169</id>

    <published>2012-01-13T21:02:13Z</published>
    <updated>2012-01-13T21:25:47Z</updated>

    <summary>The October Man (1947): Seriously brain injured in a bus crash (which takes the life of his young companion), a recovered, but terribly guilt-ridden, man (John Mills) is suspected of murdering a needy female acquaintance. Given his mental handicap, he,...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        The October Man (1947): Seriously brain injured in a bus crash (which takes the life of his young companion), a recovered, but terribly guilt-ridden, man (John Mills) is suspected of murdering a needy female acquaintance. Given his mental handicap, he,...
        
    </content>
</entry>

<entry>
    <title>They&apos;re Baaack: Plaintiffs Continue to Seek Injunction Against Federally Funded Stem-Cell Research</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2012/01/theyre-baaack-plaintiffs-appeal-hesc-ruling.html" />
    <id>tag:bmartinmd.com,2012://1.1168</id>

    <published>2012-01-13T14:42:27Z</published>
    <updated>2012-01-13T15:32:13Z</updated>

    <summary>Sherley et al v Sebelius et al. The case that won&apos;t go away...to the chagrin of scientists who rely on government funding for research with human embryonic stem cells (hESCs).The Nature News Blog reports today that scientists James Sherley and...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Legal" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Legislation" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="stemcells" label="stem cells" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Sherley et al v Sebelius et al. The case that won&apos;t go away...to the chagrin of scientists who rely on government funding for research with human embryonic stem cells (hESCs).The Nature News Blog reports today that scientists James Sherley and...
        
    </content>
</entry>

<entry>
    <title>Amyloid Burden in Cognitively Normal Elderly: What Does It Mean?</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2011/12/amyloid-cognitively-normal.html" />
    <id>tag:bmartinmd.com,2011://1.1166</id>

    <published>2011-12-22T16:17:04Z</published>
    <updated>2011-12-22T18:23:26Z</updated>

    <summary>About one-third of cognitively normal elderly demonstrate an elevated load of beta-amyloid,* a pathologic hallmark of Alzheimer disease, in the brain, according to a newly published study from the Mayo Clinic. These data support previous observations, in which the PET-imaged...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Ethics" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neurology" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Neuropsychiatry" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="alzheimersdisease" label="Alzheimer&apos;s disease" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="amyloid" label="amyloid" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        About one-third of cognitively normal elderly demonstrate an elevated load of beta-amyloid,* a pathologic hallmark of Alzheimer disease, in the brain, according to a newly published study from the Mayo Clinic. These data support previous observations, in which the PET-imaged...
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #189</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2011/12/kickback-friday-189.html" />
    <id>tag:bmartinmd.com,2011://1.1164</id>

    <published>2011-12-17T03:38:17Z</published>
    <updated>2011-12-17T04:19:33Z</updated>

    <summary>My Foolish Heart (1949): A major weepie with Susan Hayward. As an alcoholic and terribly unhappy wife, Hayward recounts the lost love of her life to a visiting college chum. The movie, which is oh-so-loosely based on* J. D. Salinger&apos;s...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        My Foolish Heart (1949): A major weepie with Susan Hayward. As an alcoholic and terribly unhappy wife, Hayward recounts the lost love of her life to a visiting college chum. The movie, which is oh-so-loosely based on* J. D. Salinger&apos;s...
        
    </content>
</entry>

<entry>
    <title>World&apos;s Largest Drug Maker &quot;Lets Go&quot;</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2011/12/worlds-largest-drug-maker-lets-go.html" />
    <id>tag:bmartinmd.com,2011://1.1163</id>

    <published>2011-12-16T20:55:43Z</published>
    <updated>2012-01-25T18:12:34Z</updated>

    <summary>First Jeffrey Kindler, then Lipitor, and now this: Pfizer announced today that it&apos;s* its dependency on the FDA&apos;s approval is over. * Bloody hell....</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="FDA" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Media" scheme="http://www.sixapart.com/ns/types#category" />
    
        <category term="Pharma" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="pfizer" label="Pfizer" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        First Jeffrey Kindler, then Lipitor, and now this: Pfizer announced today that it&apos;s* its dependency on the FDA&apos;s approval is over. * Bloody hell....
        
    </content>
</entry>

<entry>
    <title>Kick-Back Friday: #188</title>
    <link rel="alternate" type="text/html" href="http://bmartinmd.com/2011/12/kickback-friday-188.html" />
    <id>tag:bmartinmd.com,2011://1.1162</id>

    <published>2011-12-10T02:07:29Z</published>
    <updated>2011-12-10T15:10:00Z</updated>

    <summary>Tinker, Tailor, Soldier, Spy (1979): The faithfully adapted 7-part BBC mini-series of John Le Carre&apos;s titular novel—a story as much about of the banality of espionage during the Cold War, as it is about the treachery. Starring the (nearly) incomparable...</summary>
    <author>
        <name>bmartin</name>
        <uri>http://www.pathophilia.com</uri>
    </author>
    
        <category term="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#category" />
    
    <category term="kickbackfriday" label="Kick-Back Friday" scheme="http://www.sixapart.com/ns/types#tag" />
    <category term="movie" label="movie" scheme="http://www.sixapart.com/ns/types#tag" />
    
    <content type="html" xml:lang="en" xml:base="http://bmartinmd.com/">
        Tinker, Tailor, Soldier, Spy (1979): The faithfully adapted 7-part BBC mini-series of John Le Carre&apos;s titular novel—a story as much about of the banality of espionage during the Cold War, as it is about the treachery. Starring the (nearly) incomparable...
        
    </content>
</entry>

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